Avaliação in vivo da biocompatibilidade e capacidade osteoindutora do nitrato de gálio combinado ao sulfato de cálcio

Abstract

Calcium sulfate currently presents itself as a biomaterial optional to fill procedures of pathological bone cavities and dental alveoli after tooth extractions in oral rehabilitation with dental implants, as it presents many studies in the literature, can be obtained in large quantities and has a long history as auxiliary material in the process of bone regeneration. However, as no osseous inducers or osteogenic properties, their clinical applications are limited, being associated with autogenic bone in most cases. In this context, the gallium based compounds have recognized osteoinductive capacity, being used by Medicine a few years ago. This work studied in vivo gallium nitrate combined with calcium sulfate, to analyze the behavior of these histologically biomaterials. Therefore, were used 12 young adult rats of Wistar strain, which was detected two defects during the experiments in the skull of each animal, being in one hand the control, filled only with blood clot and the otherside the experimental group I, which was filled with calcium sulfate and group II with calcium sulfate associated with gallium nitrate 1% by weight. After thirty days the animals were sacrificed and specimens underwent histomorphometric analysis and SEM. The results showed evidence of systemic action of gallium nitrate in local use, however more studies must be done to demonstrate the effect antiresorptive and osteoinductive this biomaterial.