Presença de papilomavírus humano (HPV) em esfoliado das lesões orais leucoplásicas e carcinoma epidermoide de boca

Abstract

Leukoplakia are the most common cancerous lesions of the mouth and Squamous Cell of Oral Carcinoma, representing 95% of malignant oral neoplasms. Studies correlating human papilloma (HPV) with mouth cancer has grown, although they’re controversial. Therefore, this work aimed to detect the presence of HPV-DNA in exfoliated oral Leukoplasic and Oral Carcinoma. The socioeconomic and clinical data of the patients were obtained by consulting the medical records, mixed questionnaire and anamnesis of intraoral clinical examination. For the detection of HPV by Polymerase Chain Reaction (PCR), exfoliated cells obtained from the surface of the observed lesions and from other regions of the oral cavity were used. For histopathological analysis, samples of lesions were collected by incisional biopsy. The results showed a frequency of 25.64% for DNAHPV in the oral cavity, with most samples being positive for carcinoma or moderate dysplasia (7.69%). Most patients positive for DNA-HPV were male, with a mean age of 54.6 years, with the main risk behaviors being non-use of condoms (80%), tobacco use (70%), use of dental prostheses (50%) and alcohol consumption (40%). This study demonstrated a high frequency of HPV-DNA in patients with oral lesions and oral squamous cell carcinoma, as well as a profile of risk habits predisposing to infection