Use este identificador para citar ou linkar para este item: https://repositorio.ufms.br/handle/123456789/752
Tipo: Artigo de Periódico
Título: Chemical modifications of a natural xanthone and antimicrobial activity against multidrug resistant Staphylococcus aureus and cytotoxicity against human tumor cell lines
Autor(es): Micheletti, Ana Camila
Honda, Neli Kika
Lima, Dênis Pires de
Beatriz, Adilson
Sant'ana, Maria Rita
Carvalho, Nádia Cristina Pereira
Matos, Maria de Fatima Cepa
Queiróz, Lyara Meira Marinho
Bogo, Danielle
Zorzatto, José Roberto
Abstract: A series of 15 ω-aminoalkoxylxanthones containing methyl, ethyl, propyl, tert-butylamino and piperidinyl moieties were synthesized from a natural xanthone isolated from a lichen species. These compounds were tested for their in vitro antibacterial properties against Gram-positive and Gram-negative bacteria and cytotoxicity against a number of human tumor cell lines was too evaluated. The newly synthesized derivatives revealed selective activity against Staphylococcus aureus (Gram-positive), and the most promising results are for a multidrug resistant strain, for which six of these compounds showed good activity (MICs 4 µg/mL). Many derivatives inhibited tumor cells growth and most compounds were active on multiple lines.
Palavras-chave: Xantonas
Staphylococcus Aureus
Linhagem Celular Tumoral
Xanthones
Cell Line, Tumor
Editor: Química Nova
Citação: MICHELETTI, Ana Camila et al . Chemical modifications of a natural xanthone and antimicrobial activity against multidrug resistant Staphylococcus aureus and cytotoxicity against human tumor cell lines. Quím. Nova, São Paulo, v. 34, n. 6, 2011 . Disponível em <http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422011000600019&lng=pt&nrm=iso>. acessos em 07 nov. 2011. http://dx.doi.org/10.1590/S0100-40422011000600019.
Tipo de Acesso: Acesso Aberto
Identificador DOI: http://dx.doi.org/10.1590/S0100-40422011000600019
URI: https://repositorio.ufms.br/handle/123456789/752
Data do documento: 2011
Aparece nas coleções:FAENG - Artigos publicados em periódicos

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