Avaliação dos efeitos da acetona cianidrina em modelo experimental de carcinoma (4T1LUC) em camundongos

Abstract

Aiming to evaluate the antitumor effect of acetone cyanohydrin in a murine carcinoma model (4T1LUC). Twelve mice of the hairless lineage (HRS/J) were used, being 06 males and 06 adult females and male weights ranging from 20 – 25g. They were distributed into a control group and a treated group, which received acetone cyanohydrin at a dose of 1mg/kg intraperitoneally on the seventh and twelfth day after inoculation and were euthanized three days after the last application. All animals were submitted to X-ray to verify the presence or absence of the tumor. In treated males and females, there was growth of the tumor inoculated via the SC route and there was no growth of the tumor inoculated via the IP route. In untreated males and females there was tumor growth via SC route and there was no growth of tumor inoculated via IP route. Research related to the fight against cancer has provided undeniable important advances regarding the complexity of tumor development, especially regarding the molecular processes that constitute the structure that allows or allows the progressive transformation of healthy cells into extremely derivatives evil ones.