Função pulmonar e índice de oxigenação de recém-nascidos pré-termo submetidos à inalação endotraqueal de beclometasona e furosemida

Abstract

The aim of this study was to evaluate the pulmonary function and the oxygenation index of preterm infants undertaking endotracheal inhalation therapy with beclomethasone and furosemide. 30 newborn infants were evaluated, ≤ 36 week-gestation, inadequate weight or not, undertaking conventional mechanic ventilation (CMV) for at least 12 hours. The infants were randomly subdivided in three groups, 10 of them being put in the group beclomethasone (BG), 10 in the group furosemid (GF) and 10 in the control group. Three sequential inhalations with the respective drugs were made, with a three-hour break between them. After endotracheal aspiration, we measured the respiratory variables, dynamic complacency, respiratory tract resistance and oxygenation index twice, before the beginning of the inhalations and two hours after the last inhalation, using a pneumotacography. Blood samples were taken to analyze the blood gases. The statistic analysis was made using a paired student’s t-test (α=5%). The respiratory variable for dynamic complacency did not show significant statistic difference before and after the drug use (p=0,18), and neither did the oxygenation level with (p=0,47). The respiratory tract resistance showed a decrease in the group beclomethasone in the periods before and after the intervention (p=0,03). Because of these results, we cannot conclude that the inhaled beclomethasone and furosemide had significant influence in the pulmonary function and oxygenation index of the studied infants. We suggest caution in the use of this treatment in preterm infants, until decisive scientific evidence is available.