Análise dos efeitos do exercício físico em um modelo de Insuficiência Renal Crônica em Coelhos

Abstract

The Chronic Kidney Disease is associated with systemic changes that lead the renal patient to physical inactivity and serious physical deconditioning. Muscle function decreases due to disorders that can be upgraded independently of strategies that address the primary disease. The programmed exercise can bring significant benefits and provide better quality of life. The objective of this research was to analyze the effect of aerobic exercise and resistance exercise, through the Histopathological Analysis (muscular, renal, cardiac and lung) and blood Biochemistry (urea, creatinine) in an animal model of chronic renal failure in rabbits. Were used 28 rabbits varieties White New Zealand. The animals were submitted to surgical procedure of ischemia and Reperfusion. After 6 weeks of surgery the animals were divided into three groups randomized to the realization of the Protocol of exercise: aerobic exercise group (GA), group resisted exercise (GR) and control group (GC). Blood collections were performed (urea, creatinine) in three moments: pre-operation, pre-intervention (after 6 weeks postoperatively) and post-intervention (after 8 weeks of physical training). For histopathological analysis was found in cardiac and skeletal muscle, kidney, and lung. For statistical analysis of quantitative variables, the results were expressed as mean and standard deviation. The results of the qualitative variables were expressed as percentage. For repeated measures comparison, we used analysis of variance ANOVA (two-way) followed by the Tukey post hoc test Test, statistical significance was established for α = 5% (p < 0.05). The values obtained for urea presented a gradual increase so far pre-intervention (p < 0.05), and returned to reduce. Creatinine levels have progressively increased over time preoperative collection continuing in elevation in the post-intervention time (< p 0.05). The Histopathological Analysis showed systemic injuries: left and right kidney, heart, lungs. However were not identified muscle injuries detectable to the method used. The animal model in rabbits showed to be viable and effective due to systemic lesions identified, good survival of animals and the possibility of executing the exercise.