Efeito do meloxican e laser de baixa intensidade na terapêutica de lesões musculares induzidas em ratos

Abstract

Objective: To assess the effect of laser, meloxicam and laser associated to meloxicam in the collagen genesis type I and III in muscle injury induced by impact on mice on 3rd, 7th and 15th days of evaluation. Method: 60 animals (rattus Norvegicus) were used in this study, divided in four groups: injury group, laser group, meloxicam group, and laser associated to meloxicam group. The animals had muscle injury induced by impact and evaluations were made on 3rd, 7th and 15th days post-treatment. After this period, the mice were euthanized for further analysis of the results. The histological analysis was carried out through slides stained with Picrosirius Red and the collagen was quantified with CFC_image V.1.0. software. Results: The intra-group analysis was statistically significant only in the injury group and laser group for collagen type I and type III. The inter-group analysis was statistically significant for collagen type I and type III only in the laser group and laser associated to meloxicam group on the 3rd day of assessment. Conclusion: Collagen type I and type III in the laser group presented different behavior when compared to other treatment groups. For collagen type I, there was a gradual increase in the proliferation through the days. For collagen type III, there was a gradual decrease through the days. The association of laser and meloxicam and the use of meloxicam presented similar patterns to the injury group. In relation to the proliferation of collagen, the laser group proved to be more balanced, and this may reduce the formation process of fibrosis.