Avaliação da Atividade Antimicrobiana de Formulações Cremes Contendo Sulfacetamida Sódica Associada ao Ácido Gálico por Difusão em Poço

Abstract

Bacterial skin infections have Staphylococcus aureus and group A streptococci as the main causative agents. Microbial resistance represents a growing challenge to the efficacy of conventional antimicrobial treatments, especially in skin infections. The aim of this study was to develop and evaluate creamy formulations containing sodium sulfacetamide, isolated and associated with gallic acid, with the research question: 'does the addition of gallic acid enhance the antimicrobial activity, allowing for a reduction in the sulfacetamide concentration?'. Formulations were prepared by varying the concentrations of both active ingredients and a standardized well diffusion protocol was established using Mueller–Hinton agar molded with sterile tips. Samples were tested against Staphylococcus aureus and Escherichia coli. The formulations showed good physical stability. The results suggest that the combination of active ingredients enabled an enhancement in the antimicrobial effect against Staphylococcus aureus, but had no effect against Escherichia coli.