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https://repositorio.ufms.br/handle/123456789/631
Tipo: | Artigo de Periódico |
Título: | Development and validation of UV spectrophotometric method for determination of levofloxacin in pharmaceutical dosage forms |
Autor(es): | Kassab, Nájla Mohamad Amaral, Marcos Serrou do Singh, Anil Kumar Santoro, Maria Inês Rocha Miritello |
Abstract: | The objective of this research was to develop and validate an alternative analytical method for quantitative determination of levofloxacin in tablets and injection preparations. The calibration curves were linear over a concentration range from 3.0 to 8.0 μg mL-1. The relative standard deviation was below 1.0% for both formulations and average recovery was 101.42 ± 0.45% and 100.34 ± 0.85% for tablets and injection formulations, respectively. The limit of detection and limit of quantitation were 0.08 and 0.25 μg mL-1, respectively. It was concluded that the developed method is suitable for the quality control of levofloxacin in pharmaceuticals formulations. |
Palavras-chave: | Fluoroquinolonas Espectrofotometria Controle de Qualidade Fluoroquinolones Spectrophotometry Quality Control |
Editor: | Química Nova |
Citação: | KASSAB, Nájla Mohamad et al . Development and validation of UV spectrophotometric method for determination of levofloxacin in pharmaceutical dosage forms. Quím. Nova, São Paulo, v. 33, n. 4, 2010 . Disponível em <http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422010000400037&lng=pt&nrm=iso>. acessos em 24 out. 2011. http://dx.doi.org/10.1590/S0100-40422010000400037. |
Tipo de acesso: | Acesso Aberto |
Identificador DOI: | http://dx.doi.org/10.1590/S0100-40422010000400037 |
URI: | https://repositorio.ufms.br/handle/123456789/631 |
Data do documento: | 2010 |
Aparece nas coleções: | CCBS - Artigos publicados em periódicos |
Arquivos associados a este item:
Arquivo | Descrição | Tamanho | Formato | |
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Development and validation.pdf | 210,61 kB | Adobe PDF | ![]() Visualizar/Abrir |
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