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https://repositorio.ufms.br/handle/123456789/4923| Tipo: | Artigo de Periódico |
| Título: | Cognitive processes affect the gait of subjects with Parkinson’s and Alzheimer’s disease in dual tasks |
| Título(s) alternativo(s): | Processos cognitivos afetam a marcha de sujeitos com doença de Parkinson e de Alzheimer em duplas tarefas |
| Autor(es): | Christofoletti, Gustavo Felippe, Lílian Assunção Müller, Paulo de Tarso Beinotti, Fernanda Borges, Guilherme |
| Resumo: | Objetivo Investigar a relação entre parâmetros da marcha e comprometimento cognitivo em sujeitos com doença de Parkinson (DP) e doença de Alzheimer (DA) durante tarefas duplas. Métodos Este estudo consistiu em uma pesquisa transversal envolvendo 126 sujeitos, divididos em três grupos: grupo Parkinson (n = 43), grupo Alzheimer (n = 38) e grupo controle (n = 45). Os sujeitos foram submetidos ao teste Timed Up and Go, administrado com distrator motor e cognitivo. Os parâmetros analisados na marcha foram cadência e velocidade, tendo as funções cognitivas avaliadas por meio da Bateria Breve de Rastreio Cognitivo e do Teste do Desenho do Relógio. Os procedimentos estatísticos incluíram a análise mista de variâncias para observar os padrões da marcha nos grupos e nas tarefas e o modelo de regressão linear para investigar a influência das funções cognitivas nesse processo. O nível de significância foi estipulado em 5%. Resultados Em relação à velocidade, os dados vislumbram diferença significativa na interação grupo vs. tarefa (p = 0,009), com pior rendimento dos sujeitos com DP na dupla tarefa motora e dos com DA na situação de dupla tarefa cognitiva. Sobre a cadência, os resultados não apontaram diferença significativa na interação grupo vs. tarefa (p = 0,105), vislumbrando pouca interferência das condições clínicas sobre esse parâmetro. O modelo de regressão linear demonstrou que até 45.79% da variação nos parâmetros da marcha podem ser explicados por processos cognitivos. Conclusão Atividades de dupla tarefa afetam a marcha de sujeitos com DA e DP. A diferença entre grupos reflete peculiaridades de cada doença e demonstra interferência direta de processos cognitivos em atividades complexas. |
| Abstract: | Objective To investigate the relation between gait parameters and cognitive impairments in subjects with Parkinson’s disease (PD) and Alzheimer’s disease (AD) during the performance of dual tasks. Methods This was a cross-sectional study involving 126 subjects divided into three groups: Parkinson group (n = 43), Alzheimer group (n = 38), and control group (n = 45). The subjects were evaluated using the Timed Up and Go test administered with motor and cognitive distracters. Gait analyses consisted of cadence and speed measurements, with cognitive functions being assessed by the Brief Cognitive Screening Battery and the Clock Drawing Test. Statistical procedures included mixed-design analyses of variance to observe the gait patterns between groups and tasks and the linear regression model to investigate the influence of cognitive functions in this process. A 5% significant level was adopted. Results Regarding the subjects’ speed, the data show a significant difference between group vs task interaction (p = 0.009), with worse performance of subjects with PD in motor dual task and of subjects with AD in cognitive dual task. With respect to cadence, no statistical differences was seen between group vs task interaction (p = 0.105), showing low interference of the clinical conditions on such parameter. The linear regression model showed that up to 45.79%, of the variance in gait can be explained by the interference of cognitive processes. Conclusion Dual task activities affect gait pattern in subjects with PD and AD. Differences between groups reflect peculiarities of each disease and show a direct interference of cognitive processes on complex tasks. |
| Palavras-chave: | Parkinson disease Alzheimer disease gait locomotion cognitive functions |
| CNPq: | Fisioterapia e Terapia Ocupacional |
| Idioma: | eng |
| País: | Brasil |
| Citação: | Scaglioni-Solano P, Aragón-Vargas LF. Age-related differences when walking downhill on different sloped terrains. Gait Posture. 2015;41(1):153-8. 2 Christofoletti G, Oliani MM, Gobbi LTB, Gobbi S, Stella F. Risco de quedas em idosos com doença de Parkinson e demência de Alzheimer: um estudo transversal. Rev Bras Fisioter. 2006;10(4):429-33. 3 Stevenson AJ, Geertsen SS, Sinkjaer T, Nielsen JB, Mrachacz-Kersting N. Interlimb communication following unexpected changes in treadmill velocity during human walking. J Neurophysiol. 2015. 4 Richard MA, Spaich EG, Serrao M, Andersen OK. Stimulation site and phase modulation of the withdrawl reflex during gait imitation. Clin Neurophysiol. 2015. Kandel ER, Schwartz JH, Jessel TM. Principles of neural science. 4th ed. New York: McGraw Hill; 2000. 5 Kandel ER, Schwartz JH, Jessel TM. Principles of neural science. 4th ed. New York: McGraw Hill; 2000. 6 Kandel ER, Schwartz JH, Jessel TM. Essentials of neural science and behavior. Stamford: Appleton & Lange; 1996. 7 Strobach T, Soutschek A, Antonenko D, Flöel A, Schubert T. Modulation of executive control in dual tasks with transcranial direct current stimulation (tDCS). Neuropsychologia. 2015;68:8-20. 8 Muir SW, Beauchet O, Montero-Odasso M, Annweiler C, Fantino B, Speechley M. Association of executive function impairment, history of falls and physical performance in older adults: a cross-sectional population-based study in eastern France. J Nutr Health Aging. 2013;17(8):661-5. 9 Montero-Odasso M, Verghese J, Beauchet O, Hausdorff JM. Gait and cognition: a complementary approach to understanding brain function and the risk of falling. J Am Geriatr Soc. 2012;60(11):2127-36. 10 Vink M, Kleerekooper I, van den Wildenberg WP, Kahn RS. Impact of aging on frontostriatal reward processing. Hum Brain Mapp. 2015;36(6):2305-17. 11 Beurskens R, Bock O. Age-related deficits of dual-task walking: a review. Neural Plast. 2012;2012:131608. 12 Jové M, Portero-Otín M, Naudí A, Ferrer I, Pamplona R. Metabolomics of human brain aging and age-related neurodegenerative diseases. J Neuropathol Exp Neurol. 2014;73(7):640-57. 13 Christofoletti G, Andrade LP, Beinotti F, Borges G. Cognition and dual-task performance in older adults with Parkinson’s and Alzheimer’s disease. Int J Gen Med. 2014;7:383-8. 14 Chu YH, Tang PF, Peng YC, Chen HY. Meta-analysis of type and complexity of a secondary task during walking on the prediction of elderly falls. Geriatr Gerontol Int. 2013;13(2):289-97. 15 Hughes AJ, Daniel SE, Kilford L, Lees AJ. Accuracy of clinical diagnosis of idiopathic Parkinson’s disease: a clinicopathological study of 100 cases. J Neurol Neurosurg Psychiatry. 1992;55(3):181-4. 16 Hoehn MH, Yahr MD. Parkinsonism: onset, progression and mortality. Neurology. 1967;17(5):427-42. 17 Fahn S, Elton RL. Unified Parkinson’s Disease Rating Scale. In: Fahn S, Marsden CD, Goldstein M, Calne DB. Recent developments in Parkinson’s disease. New York: MacMillan; 1987. p. 153-63. 18 Mckhann G, Drachman D, Folstein M, Katzman R, Price D, Stadlan EM. Clinical diagnosis of Alzheimer’s disease: report of this NINCDS-ADRDA work group under the auspices of Department of Health and Human Services Task Force on Alzheimer’s disease. Neurology. 1984;34(7): 934-44. 19 Hughes CP, Berg L, Danziger WL, Coben LA, Martin RL. A new clinical scale for the staging of dementia. Br J Psychiatry. 1982;140:566-72. 20 von Elm E, Altman DG, Egger M, Pocock SJ, Gøtzsche PC, Vandenbroucke JP; STROBE Initiative. The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: guidelines for reporting observational studies. J Clin Epidemiol. 2008;61(4):344-9. 21 Podsiadlo D, Richardson S. The ‘Timed Up and Go’: a test of basic functional mobility for frail elderly persons. J Am Geriatr Soc. 1991;39(2):142-8. 22 Ries JD, Ecternach JL, Nof L, Gagnon Blodgett M. Test-retest reliability and minimal detectable change scores for the timed “up & go” test, the six-minute walk test, and gait speed in people with Alzheimer’s disease. Phys Ther. 2009;89(6):569-79. 23 Pfeffer RI, Kurosaki TT, Harrah CH, Chance JM, Filos S. Measurement of functional activities in older adults in the community. J Gerontol. 1982;37(3):323-9. 24 Nitrini R, Lefèvre BH, Mathias SC, Caramelli P, Carrilho PE, Sauaia N, et al. Neuropsychological tests of simple application for diagnosing dementia. Arq Neuropsiquiatr. 1994;52(4):457-65. 25 Sunderland T, Hill JL, Mellow AM, Lawlor BA, Gundersheimer J, Newhouse PA, et al. Clock drawing in Alzheimer’s disease. A novel measure of dementia severity. J Am Geriatr Soc. 1989;37(8):725-9. 26 Chiba H, Ebihara S, Tomita N, Sasaki H, Butler JP. Differential gait kinematics between fallers and non-fallers in community-dwelling elderly people. Geriatr Gerontol Int. 2005;5(2):127-34. 27 Fernández MDP, Arias P, Cudeiro-Mazaira FJ. Facilitación de la actividad motora por estímulos sensoriales en la enfermedad de Parkinson. Rev Neurol. 2004;39(9):841-7. 28 Yogev-Seligmann G, Hausdorff JM, Giladi N. The role of executive function and attention on gait. Mov Disord. 2007;23(3):329-42. 29 Felippe LA, Oliveira RT, Silva-Hamu TCD, Santos SMS, Christofoletti G. Funções executivas, atividades da vida diária e habilidade motora de idosos com doenças neurodegenerativas. J Bras Psiquiatr. 2014;63(1):39-47. 30 Marshall GA, Monserratt L, Harwood D, Mandelkern M, Cummings JL, Sultzer Dl. Positron emission tomography metabolic correlates of apathy in Alzheimer’s disease. Arch Neurol. 2007;64(7):1015-20. 31 Schroeter ML, Stein T, Maslowswki N, Neumann J. Neural correlates of Alzheimer’s disease and mild cognitive impairment: a systematic and quantitative meta-analysis involving 1351 patients. Neuroimage. 2009;47(4):1196-206. 32 Mirelman A, Herman T, Brozgol M, Dorfman M, Sprecher E, Schweiger A, et al. Executive function and falls in older adults: new findings from a five-year prospective study link fall risk to cognition. PLoS One. 2012;7(6):e40297. 33 Nordin E, Moe-Nilssen R, Ramnemark A, Lundin-Olsson L. Changes in step-width during dual-task walking predicts falls. Gait Posture. 2010;32(1):92-7. |
| Tipo de acesso: | Acesso Aberto Attribution-NonCommercial-ShareAlike 3.0 Brazil |
| metadata.dc.rights.uri: | http://creativecommons.org/licenses/by-nc-sa/3.0/br/ |
| Identificador DOI: | https://doi.org/10.1590/0047-2085000000071 |
| URI: | https://repositorio.ufms.br/handle/123456789/4923 |
| Data do documento: | 2015 |
| Aparece nas coleções: | INISA - Artigos publicados em periódicos |
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