PERFIL DE CITOCINAS EM PACIENTES COM CERVICITE, LESÕES CERVICAIS OU CARCINOMA CERVICAL

Abstract

Human papillomavirus (HPV) is an infectious agent that induce to chronic infections without systemic repercussions, and this occurs for several reasons, such as: being exclusively intraepithelial, not promoting inflammation or cell lysis, causing little or no viremia, of course way, not activating the early warning mechanisms of the innate immune system. It is known that due to the mechanisms by which HPV-infected cells escape immunological surveillance, including the decrease and/or alteration of the cytokine profile, the persistence of viral infection may occur and thus culminate in cellular changes such as high-grade squamous intraepithelial lesion (HSIL) and Cervical Carcinoma (CC). The study of cytokine profiles is extremely relevant for a better understanding of HPV infection and the host's immune response, thus providing a more enlightening understanding of cytokines as biomarkers, enabling the search for new drugs, diagnostic and treatments. The aim of this study was to detect the cytokine profile in patients with cervicitis, cervical lesions or cervical carcinoma. For this purpose, a descriptive, observational, cross-sectional research was carried out involving patients treated at the Hospital de Amor, Campo Grande - MS unit in 2019 and 2020, where patients undergoing cervical cytology, cervical biopsy were selected, and screening for high oncogenic risk HPV (HR-HPV) by the Cobas® HPV Test method. Sixty-six patients aged between 25 and 65 years (mean 42.29 years) were included in the study. Cytokine analysis in patients with cervicitis, cervical lesions or cervical carcinoma have showed that IL-6 is in higher concentration in patients positive for HPV16 than in patients who positive for other HR-HPV (p<0.05). IL-17 was present in higher concentration in patients with cervicitis, HSIL and carcinoma also HPV negative patients, although these results were not significant.