Toxoplasmose aguda: estudo da transmissão vertical e fatores relacionados à infecção fetal e neonatal

Abstract

Purpose: to identify the frequency of pregnant IgM reagent for toxoplasmosis and the results of the test of avidity for toxoplasmosis. To assess the epidemiological profile and the average time between diagnosis and initiation of treatment. Check the rate of vertical transmission of acute toxoplasmosis. To evaluate the association of the test results of greed and the presence of congenital infection. Identify the sensitivity, specificity of the test of greed. To evaluate the association at the time of diagnosis and the presence of congenital infection Methods: Study cross with 176 women and 165 children born, subjected to pre-natal screening from November 2002 to November 2007. The evaluation of the variables was performed by the medium, and the correlation between some variables was evaluated by testing the X2 or twosided Fisher’s exact test in contingency tables. Result: it was found the frequency of 10.8% for the acute infection T. gondii in pregnant women, 88,9% with high avidity.O average time between diagnosis and initiation of treatment was 8.3 weeks. The rate of vertical transmission was 4%. There were statistical association (p = 0003) between the test results of avidity and fetal infection fetal / neonatal. The avidity IgG test for the prediction of infection fetal / neonatal in pregnant women showed a specificity of 91% and negative predictive value of 98%. Conclusions: the frequency of acute maternal toxoplasmosis was above the observed in Brazil. The average time between diagnosis and initiation of treatment far above the desirable. There were statistical association of the test results of greed and the presence of infection fetal / neonatal.