Estudo comparativo entre a cola de fibrina e o plasma rico em plaquetas em enxertos cutâneos em cães

Abstract

Skin grafts in dogs are mainly used in large skin loss in the distal regions of limbs. Fibrin glue and platelet-rich plasma act as adjuvants in the healing skin. The aim of this study was to compare fibrin glue (Tissucol ®) and platelet-rich plasma on skin grafts, full thickness mesh in dogs. Were used 18 dogs divided into two groups, fibrin glue (CF) and platelet-rich plasma (PRP). In all animals we performed a skin graft from 3x3 cm full-thickness mesh. In the left limb was placed between the graft and receptor bed, the biomaterial each in their group, and the right limb served as control. All animals were clinically evaluate 48 hours until the fourteenth day, through the variables: exudation, color, edema and cosmetic appearance; and three of them were evaluate histologically in the third, seventh and fourteenth days postoperatively through the variables autolysis, fibroblasts , collagen, granulation tissue, adhesion-integrating microscopic and acute inflammation. By testing statistically significant (P <0.05), it was concluded that fibrin glue group was clinically superior to the group platelet-rich plasma when used in full thickness skin grafts in dogs.