Efeito do extrato etanólico de Moquiniastrum polymorphum sobre a carcinogênese colorretal induzida por 1,2 dimetilhidrazina

Abstract

This study aimed to evaluate the effect of the Moquiniastrum polymorphum ethanol extract (MPEE) on 1.2 dimethylhydrazine (DMH)-induced colorectal carcinogenesis. Forty-two male Swiss mice (Mus musculus) were distributed into six groups (n=7/group): control, DMH, EEMP, pre-treatment, simultaneous and post-treatment. The findings indicated that the EEMP is antigenotoxic because the damage reduction percentages (DR%) through the comet assay were more than 81% in the associated groups. The agent also showed antimutagenic activity, because the micronucleus test found DR% higher than 77.09 in the associated groups. The aberrant crypts foci test demonstrated the high anticarcinogenic potential of the MPEE as the associated groups showed DR% 62.13, 86.40 and 95.14 for pretreatment, simultaneous and post-treatment groups, respectively. The study shows that the MPEE in nontoxic and has chemopreventive and anticarcinogenic activity, thus the agent may prove to be a promising herbal medicine in view of its demonstrated properties.