Doença falciforme, zinco e TBARS

Abstract

The main objective of this study is to analyze TBARS and zinc plasmatic concentrations in sickle cell disease individuals using hydroxyurea. It is a descriptive cross-sectional study, from March 2011 to December 2015. Twenty-four patients, men and women, from Campo Grande, MS, were studied for plasma levels of TBARS and zinc. Clinical and survival features were reviewed in literature. . To compare the means it was performed the t test or Mann-Whitney test, normality was verified by the Shapiro-Wilk test. For correlations, it was performed Pearson or Spearman test at a significance level of 5%. Results Zinc values ranged from 36.0 to 74,4mg / L, with a mean of 50.1 ± 9,5mg / L (SD), TBARS ranged from 2.46 to 21.97 μmol with average of 9.92 ± 6.18 μmol (DP). There was a strong negative correlation between TBARS and HbF (r = -0.82). Conclusion: There was a reduction of plasma zinc concentrations in Sickle Cell Disease when compared with control group. Persistence of oxidative stress markers (TBARS) although hydroxyurea uses for a long period of time. The higher fetal hemoglobin, the lower oxidative stress. The results were similar to those observed in the literature. Despite the regular use of Hydroxyurea, the Sickle Cell Disease group had elevated TBARS and reduced zinc.