Efeitos da hiperóxia variável no estresse oxidativo e histopatologia de ratos recém-desmamados

Abstract

In order to analyze the changes in plasma and lung tissue of weanling rats with oxygen therapy by evaluating MDA and lung histopathology were used 144 Wistar rats exposed to different concentrations of O2 (21, 50, 75 and 100%). Each group was distributed into subgroups according to the exposure time (1, 2 and 3 hours), and redistributed according to the euthanasia time: immediately after treatment, and 10 days after the last exposure to O2, lungs were collected and fixed in formalin for histological analysis where variables were found able to demonstrate changes in lung architecture. High concentrations of MDA in plasma from mice were euthanized immediately after exposure to 50% oxygen fraction in oxidative stress suggests independent of time. However, it was not observed in this study the relationship between elevation of MDA levels and increased oxygen concentrations, the most frequent pulmonary changes and significant present in animals exposed to hyperoxia were hemorrhage, septal thickening and congestion, present in all groups ten days after exposure to O2, by not observing progressive fibrosis or restoration of normal alveolar architecture, it can be considered that there was no lung remodeling in animals evaluated.