Utilização de adesivos à base de cianoacrilato na síntese cutânea em ratos

Abstract

The objective of this experiment was to compare the use of a new surgical adhesive based on cyanoacrylate and suture with separate points in the closure of skin wounds. Were used 36 male Wistar Rats, who were subjected to a longitudinal incision of 4 cm on de the dorsum, in 12 the wall syntheses was made using simple suture with polyamide 6-0, 12 underwent wall syntheses using octyl-cyanoacrylate (Dermabond®) and 12 was performed cutaneous syntheses with N-2-Butyl-Cyanoacrylate. twelve animals of each group were submitted to euthanasia In the seventh postoperative day and their blood taken to biochemical tests, a layer of skin e subcutaneous tissue surrounding the surgical scar and divided incentral and lateral segments, one to the submission of rupture force tests using a tensiometer and other to histological study, evaluating the amount of collagen in the suture line. Results were analyzed according to statistical parameters. Concluded that: There wasn't biochemical alterations, demonstrating that this adhesives do not cause any system inflammation or kidney and hepatic toxicity. Polyamide sutures are more resistant and the adhesives should be used alone in less tension areas.