Infecção por citomegalovirus em pacientes internados em unidades neonatais de Campo Grande – MS, Brasil

Abstract

Introduction: Infection with cytomegalovirus (CMV) is an intrauterine infection considered the most frequent congenital infections of hematogenous transplacental transmission. Objective: To study the frequency of congenital CMV infection in newborns admitted to the Division of Neonatology by the method of molecular biology and compare the use of samples of blood and urine. Materials and Methods: The study was carried out from March 2010 to August 2012. Urine and blood of newborns hospitalized in five hospitals in Campo Grande-MS were analyzed by the method of polymerase chain reaction (nested PCR). Results: We studied 520 newborns, of these, 13 (2.5%) were positive for CMV in urine and 10 (2%) were positive for CMV in the blood. Regarding symptoms, 3 (23%) were asymptomatic and 10 (77%) symptomatic patients, 13 (100%) identified as congenital infection. The main clinical features of the patients were symptomatic: 10 (100%) were preterm, 2 (20%) had petechiae, 5 (50%), respiratory failure, 1 (10%) microcephaly, 1 (10%) and 7 hydrocephaly (70%) had jaundice. Regarding made for serology positive patients, only 1 (0.2%) showed IgG + and IgM +. As for evolution, the total positive, 1 (7.7%) resulted in death. Conclusion: The presence of genomic DNA in urine showed a higher number of CMV-positive than in blood and higher sensitivity than in serology (p = 000.1).