Prevalência de diabetes mellitus em pacientes com diagnóstico hepatite C crônica avaliados no Hospital Universitário da Universidade Federal do Mato Grosso do Sul no período de 1 ano

Abstract

OBJECTIVE: The aim of this study was to evaluate the prevalence of diabetic patients amongst those afflicted by type C hepatitis being attended at the Hospital of the Federal University of the State of Mato Grosso do Sul (UFMS). Methods: A total of 261 subjects were evaluated in the outpatient section for viral hepatitis at the Professor Esterina Corsini day clinic in the University Hospital (UFMS).These patients were divided into two groups: those with Hepatitis C (165) and those with Hepatitis B (96). The prevalence of diabetes Mellitus was calculated in both groups. Information, such as, age, body mass index (BMI), viral genotype, hepatic biopsy and the type of response to the treatment was duly studied in the patients afflicted with the hepatitis C virus. Results The prevalence of diabetes Mellitus was greater among the patients infected with Hepatitis C virus (HCV) when compared to those with chronic hepatitis B (20% vs. 6,4% - p 0,0034). The patients diagnosed with Hepatitis C and diabetes proved to be older (56 – 65 years old), with higher body mass indexes (BMI), showed more prevalence of infection by viral genotype 2, hepatic biopsies denoting a greater degree of fibrosis and lower indices of response to treatment with interferon and Ribavirin. Conclusion: The high prevalence of diabetes in patients infected by HCV, associated with the greater tendency to advanced Hepatic fibrosis and a diminished response to the treatment, suggests that the alterations in the glucose metabolism should be diagnosed earlier and treated rigorously in this group of patients.