Use este identificador para citar ou linkar para este item: https://repositorio.ufms.br/handle/123456789/1272
Tipo: Artigo de Periódico
Título: Metabolic effects associated to the highly active antiretroviral therapy (HAART) in AIDS patients
Autor(es): Domingos, Hamilton
Cunha, Rivaldo Venâncio da
Paniago, Anamaria Mello Miranda
Martins, Diego Mira
Elkhoury, Eduardo Brandão
Souza, Albert Schiaveto de
Abstract: The aim of this study was to evaluate the metabolic abnormalities (dyslipidaemia and insulin resistance) associated with highly active antiretroviral therapy (HAART) in AIDS patients, treated in Campo Grande, Mato Grosso do Sul, Brazil. The patients were distributed in five different groups: Group 1, HIV-infected without antiretroviral therapy; Group 2, with Zidovudine, Lamivudine and Efavirenz or Nevirapine; Group 3, with Zidovudine, Lamivudine and Protease Inhibitor; Group 4, with Stavudine, Lamivudine and Efavirenz or Nevirapine; and Group 5, with Stavudine, Lamivudine and Protease Inhibitor. The lipid and glucose profile were determined and statistics comparison was made. The findings of this study showed significant statistics elevations of total cholesterol and triglycerides levels in patients of Groups 3, 4 and 5, when comparing to patients of Groups 1 and 2. Significant differences were not observed between the groups in the others parameters evaluated: Glucose, HDL cholesterol and LDL cholesterol. Comparing two drugs of same class (NNRTI) through the subgroups II-efavirenz and II-nevirapine, significant differences in the serum levels of total cholesterol, triglycerides and glucose favorable to the subgroup II-NVP were observed. These findings suggest that combinations including Protease Inhibitors and/or Stavudine could cause more adverse metabolic effects, and if possible, should be avoided in patients with others cardiovascular risk factors to prevent the precocious atherosclerosis in AIDS patients receiving HAART.
Palavras-chave: Síndrome de Imunodeficiência Adquirida
Terapia AntiRetroviral de Alta Atividade
Metabolismo - efeitos de drogas
Dislipidemias
Resistência à Insulina
Acquired Immunodeficiency Syndrome
Antiretroviral Therapy, Highly Active
Metabolism - drug effects
Insulin Resistance
Editor: Brazilian Journal of Infectious Diseases
Citação: DOMINGOS, Hamilton et al . Metabolic effects associated to the highly active antiretroviral therapy (HAART) in AIDS patients. Braz J Infect Dis, Salvador, v. 13, n. 2, Apr. 2009 . Available from <http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702009000200012&lng=en&nrm=iso>. access on 18 Apr. 2012.
Tipo de Acesso: Acesso Aberto
Identificador DOI: http://dx.doi.org/10.1590/S1413-86702009000200012.
URI: https://repositorio.ufms.br/handle/123456789/1272
Data do documento: Abr-2009
Aparece nas coleções:FAMED - Artigos publicados em periódicos

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