Reação multicomponente para a amino-organilcalcogenilação de maleimidas catalisada por nanopartículas de CuO.

Abstract

The advancement of new green methodologies in organic synthesis is crucial for the safer and more sustainable production of compounds, especially in medicinal chemistry. Currently, a significant part of medicines is generated by total synthesis, where simple matter goes through several steps until the final product. Thus, continuous innovation in overview research, with an emphasis on ecological approaches, makes it possible to create new compounds through less aggressive processes. This research project aims to develop more sustainable and environmentally friendly chemical methodologies, allowing the incorporation of organochalcogen groups (such as sulfur and selenium) through a multicomponent occurrence catalyzed by copper for the functionalization of maleimides. In this context, selenium plays a fundamental role due to its high reactivity and characteristics, making it an important ally in producing medicines and agrochemicals. Therefore, the main objective of this study is to create methods aligned with the principles of green chemistry for the synthesis of maleimides with biological potential. The use of nanoparticles was investigated, and their interactions in the reaction medium and the variation in the concentration of the case were analyzed. In this context, 10 maleimide compounds were synthesized from commercial maleic anhydrides and anilines. For the chalcogenation of the derivatives, a system catalyzed by nanoparticles of copper (II) oxide, diphenyl diselenide, and secondary amines was used under optimized reaction conditions. This method resulted in the production of 26 compounds, with yields ranging from 53% to 96%. The characterization of the compounds was performed using 1 H and 13 C NMR spectroscopic techniques. These results, taken together, indicate the possibility of generating new compounds with unique properties, which are valuable in pharmaceutical research and materials chemistry.