ESTUDO DA SÍNTESE E ATIVIDADE BIOLÓGICA DE NOVAS 2-BENZILIDENOBENZOFURANO-3(2H)-ONAS BASEADAS NO CARDANOL

Abstract

The development of new compounds is a continuously expanding field in chemistry, particularly in organic synthesis, driven by the urgent need for novel drugs to combat the rising emergence of multidrug-resistant bacteria. The creation of new synthetic routes, as well as the application of established methodologies to obtain innovative compounds, represents one of the major challenges in contemporary research. In this context, this study aimed to explore different methodologies for the synthesis of aurones derived from cardanol, with the goal of evaluating their biological activity against multidrug-resistant bacteria. Initially, cardanol was purified and used as a starting material for the synthesis of acetophenone, a precursor to the chalcone under investigation, and cardanol-derived chromone, which served as a substrate for the synthesis of enaminone. Both chalcone and enaminone were employed in the synthesis of new aurones using a reaction system with refluxing DMSO as a solvent, along with copper bromide and molecular iodine as reagents. The obtained compounds were subjected to biological assays against multidrug-resistant bacteria, including Escherichia coli and Staphylococcus epidermidis, to evaluate their potential for partial or complete microbial growth inhibition. As a result, two novel molecules were synthesized, demonstrating promising potential for the development of antibacterial drugs.