Trabalho de conclusão de curso e relatório de estágio curricular obrigatório

Abstract

Economic losses, reduced productivity and death are a reflection of the performance of ruminants affected by gastrointestinal nematodes, and increasing reports of anthelmintic resistance threaten the efficient control of these helminths. The search for new antiparasitic drugs that comply with the principles of green chemistry is therefore growing. Plants represent viable and sustainable alternatives to chemicals for this, and metabolomic tools have been able to identify secondary metabolites in their structure. The aim of this work was to evaluate the in vitro ovicidal activity of 12 bioactive compounds against Haemonchus contortus, using the larval hatchability test (TEL) to find the average effective concentration (EC50) of each metabolite. All the molecules showed anthelmintic activity and lapachol, from the naphthoquinone class, had the greatest potency against H. contortus.