REPOSICIONAMENTO DE ANTI-INFLAMATÓRIOS NÃO ESTEROIDAIS PARA EFEITO ANTIMICROBIANO EM Staphylococcus aureus

Abstract

Bacterial resistance has become a major global public health problem. In this context, infections generated by Staphylococcus aureus gain importance due to the ability of this bacteria to acquire resistance mechanisms. Its sites of infection are diverse, from skin infections and soft tissues, to osteomyelitis and septicemia. This variety is enabled by devices such as virulence factors, efflux pumps, antimicrobial resistance genes, and biofilm formation. With the advance of bacterial selection and the lack of development of new antibiotics, drug repositioning appears as a resource to combat this problem. Drug repositioning uses drugs available on the market, therefore with in vitro, in vivo and pharmacokinetic studies already known. Thus, they can easily be used for new purposes, saving time and development resources. Therefore, non-steroidal anti-inflammatory drugs are a class of medications that are being used in research of antimicrobial action. The present work attempts, from a bibliographical consultation, to assess the recent panorama on the antibacterial activity of non-steroidal anti-inflammatory drugs in cultures of Staphylococcus aureus. To this end, research on the topic was carried out in the PubMed and Scopus repositories over the last ten years. The results were sorted by anti-inflammatory drugs and strains tested and compared by the minimum inhibitory concentration of each one, in order to verify the consistency of the data and the possibility of repositioning. Among the more than 13 anti-inflammatories tested, the most common was diclofenac, which is widely consumed worldwide. However, few medications offered the possibility of repositioning.