Uso de canabidiol para o tratamento de sintomas motores e não-motores na doença de Parkinson: Revisão de literatura

Abstract

Parkinson’s Disease is a neurodegenerative condition characterized by alterations in the basal ganglia, leading to the progressive degeneration of dopaminergic neurons in the substantia nigra pars compacta. Affected individuals may experience both motor symptoms and cognitive and emotional symptoms. Although the main form of treatment is pharmacological, many medications fail to treat the disease in the long term. Cannabidiol is a compound that has shown promise for the treatment of the disease, as an alternative option and complement to those available on the market. A literature review was conducted on studies addressing the effects of cannabidiol on Parkinson’s disease, and potential treatments with the compound. The multimodal capability of cannabidiol, acting on different molecular targets, makes this compound a promising medication for the treatment of Parkinson’s disease. Its mechanisms of action help alleviate the motor symptoms of the disease, and it is also capable of improving cognitive function. The various beneficial properties of cannabidiol make it a promising drug to be used as a complementary or alternative option to currently available treatments. However, more studies are needed to better understand the effects and mechanisms of action of cannabidiol in individuals affected by the disease, as the clinical trials available in the literature are often limited and involve small sample sizes.