Avaliação simultânea da força de preensão palmar e tração do membro superior em camundongos por meio de novo dinamômetro biomédico

Abstract

Changes in the integrated system of the brain and hand generate difficulties in performing functional tasks, as observed in patients diagnosed with cerebral palsy. The objective of this work is to develop a new mechatronic biomedical dynamometer. The prototype developed in the Laboratory of Biomedical Engineering and Assistive Technology (ENGEBIO) of FAMED is constituted by a metallic sheet of stainless steel AISI 420 that measures 18.5 cm in length, 1.5 cm in width and 2 mm in thickness in which the mouse applies force to a nylon line located at the end, two identical double strain gages of model pa-09-125ha-350-l8 from the manufacturer Excel Sensors (Brazil) that were glued, one on each face of the blade, a conditioning circuit of Arduino signals containing a gain amplifier G = 10,000, a 4th order Butterworth filter, a Sony Vaio FE15 i7 10a computer on which a software was developed in Labview 2019 from the National Instruments company for processing information generated by the static calibration and by the test of dynamic response performed with standardized masses that produced responses that were presented in numerical and graphical form. The main calibration results were: 15.48 g generated 3.70 V, 31.53 g generated 7.48 V and 62.47 g generated 14.80 V while for the dynamic response test the response was 0. 3 sec. The prototype of the new biomedical dynamometer was developed taking into account that there is a need for sufficient sensitivity to test the variables of interest in a future pre-clinical trial, with an animal model of mice, and, subsequently, the clinical trial in newborn children. -born with low birth weight conditions, developing neurological system, presence of primitive reflexes that demonstrate the presence of muscle tone, such as the moro reflex and the sucking reflex. The applicability of the prototype developed in this project enables the development of a pre-clinical test that will provide relevant information for the improvement of the prototype and thus base the sequence in a clinical trial to, finally, subsidize the creation of a new biomedical dynamometer with application in the diagnosis and evaluation of the cerebral palsy in children.