SÍNTESE DE DERIVADOS DA 2,3-DIHIDRO-1H-PERIMIDINA CATALISADA POR HIDROXISSAIS LAMELARES DE COBALTO – Co2(OH)3Cl

Abstract

The headway of ecological and sustainable approaches came out as one of the great areas of recent scientific research. The development of new methodologies through the modification and adaptation of established techniques in the field represents a stimulating challenge for researchers. Taking into consideration the present work intent to develop a methodology more sustainable for the synthesis of 2,3-dihydro-1H-perimidines, using as a catalyst Lamellar Cobalt Hydroxides, low toxicity and stable, by heating at 70 °C for 5 minutes without a solvent. Following that, a scope was formed with 7 examples of substituted 2,3-dihydro-1H-perimidines with excellent yields, proving the effectiveness of the methodology. Furthermore, these compounds were characterized using NMR 1H and 13C. As follows, it was possible to elaborate on a new efficient and more sustainable synthetic route for the synthesis of these compounds.