ESTUDOSPARA APREPARAÇÃO DE ANÁLOGOS CHALCÔNICOS DA PENTAMIDINA COM POTENCIAL BIOATIVO PARA TRATAMENTO DE DOENÇAS NEGLIGENCIADAS

Abstract

Recent studies show that around 2 billion people worldwide are at risk of contracting some neglected tropical disease (NTD), covering a broad group of infectious diseases. In the fight against NTDs, there is an urgent need for new research methodologies, as there are many challenges in developing new prototypes for these diseases. In Brazil, the epidemiological numbers for leishmaniasis are alarming, and the mode of transmission makes control more challenging, as this sandfly is considered endemic in all regions of the country. In a recent study by our research group (CIBSint - SINTMOL), the significant and selective antileishmania action of a set of synthetic chalcone derivatives was demonstrated. However, it is necessary to use another molecule with confirmed antileishmania activity to build new potential prototypes. In this study, we propose the synthesis of chalconic hybrids of pentamidine using a set of cost-effective and easy-to-perform reactions.