NOVOS COMPLEXOS DE Cu II BASEADOS EM LIGANTES 1,2,3-TRIAZOIS 1,4-DISSUBSTISTUIDOS COM PROMISSORA ATIVIDADE ANTILEISCHMANIA

Abstract

Leishmaniasis is considered the second most lethal parasitic disease in the world, negatively impacting the health of individual residents in intertropical and temperate regions since these regions are more conducive to the development of the mosquito vector of this disease. In Brazil, Leishmania amazonensis is the main species causing the clinical manifestations of leishmaniasis. Leishmania has gained notoriety in recent times as the number of cases in non endemic countries has increased. First and second-generation drugs have their adverse effects outweighing the benefits, which greatly impairs the treatment of the disease. With the aid of molecular modeling, several drug candidates have been developed to potentiate the biological activity against leishmaniasis, thus reducing their side effects. In this sense, compounds from the triazole family, which are defined as aromatic systems possessing a five-membered ring formed by three nitrogen atoms and two carbon atoms, have gained importance as possible bioactive substructures against Leishmaniasis. Considering the versatility of triazoles as ligands in coordination chemistry, a wide range of metal-organic compounds can be prepared and tested as new metallopharmaceutical candidates against Leishmaniasis. In this work, we describe the synthesis, structural, spectroscopic characterization, and investigation of the biological properties of new complexes containing triazoles coordinated to CuII ions. The structures of the complexes were elucidated by single-crystal X-ray diffractometry revealing a planar square coordination environment for the CuII ions present in the complexes. Biological evaluations demonstrate that the complexes are more active than their respective ligands in antibacterial as well as antitumor assays. The complete characterization of the two novel complexes synthesized in this work involved besides X-ray diffractometry, elemental analysis of CHN, vibrational spectroscopy in the infrared region, molecular absorption spectroscopy in the UV Vis and high-resolution mass spectrometry.