Efeito do exercício físico aeróbico e resistido no desenvolvimento do câncer colorretal em camundongos

Abstract

Objective: This study aimed to evaluate the action of aerobic exercise and resistance in the development of colorectal cancer induced by and Azoximethane (OAM) associated with colitis in mice. Methods: The results were obtained through an experimental study in animal model. The study was developed in the Medical Faculty Of The Federal University Of Mato Grosso do Sul, in the city of Campo Grande - MS. In this study 40 animals were used divided in 5 groups of 8 animals,G1: swimming pre and post induction, G2: vertical ladder pre and post induction, G3: swimming post induction, G4; vertical ladder post induction, G5; sedentary induced to colorectal cancer. The animals were induced to cancer with a total dose of 20 mg/Kg of azoximethane, fractionated in two weeks, 10 mg/kg per week, first dose in the third week and second dose in the fourth week. For colitis induction 3 cycles of sodium dextran sulfate (DSS) were performed for 5 days interspersed with 2 weeks of normal water. At the fourteenth week of the experiment all animals were submitted to euthanasia procedure, their colon was removed for macroscopic and microscopic analysis, and microscopy slides were made to allow the histological classification of lesions found aiming at comparing the findings in the experimental groups. Results: The five groups developed neoplastic lesions, there was no significant difference between the groups, however, the inflammatory signs, there was a significant difference in the development of mucous ulceration (p=0.016). In the development of polyps there was a significant difference in the distal region (p=0.003), medial region (p=0.04), and total number of polyps (p=0.002). Conclusion: Physical exercise did not reduce neoplastic lesions. However, it reduced the number of polyps in regions of the colon.