Análise dos níveis de GLP-1 nos estados de jejum e pósprandial durante a gestação em mulheres não diabéticas

Abstract

Introduction: Incretin hormones are produced by intestinal cells that act by stimulating the pancreas to secrete insulin. GLP-1 is the main representative of these hormones. Studies show that levels of this peptide are decreased in patients with type 2 diabetes mellitus. Objective: To describe the behavior of GLP-1 during pregnancy in non diabetic women. Patients and Method: This is a prospective longitudinal descriptive study prepared for analysis of plasma levels of GLP-1 in the first, second and third trimester of pregnancy, fasting and 30 minutes after meal of 401 kcal. Results: The median fasting GLP-1 was respectively 3.15 pmol/L, 3.16 pmol/L and 3.28 pmol/L in the first, second and third quarters. In the postprandial period, the values of the first, second, and third quarter were respectively 3.95 pmol/L, 3.94 pmol/L and 4.60 pmol/L. Statistical analysis showed no significant difference between the results. Conclusion: The results suggest that there is no change in the levels of GLP-1 during pregnancy in non diabetic women.