Prevalência de infecção por Paracoccidioides brasiliensis em pacientes com HIV/AIDS do Hospital-Dia profª Esterina Corsini, Campo Grande - MS, 2007

Abstract

Paracococcidioidomycosis (PCM) is the most important systemic mycosis in Brazil and is more common in adult men from rural areas. The association of PCM to aids has been not well observed, when compared with candidiasis, cryptococcosis and histoplasmosis. People with HIV do not present contact with the fungus because of their urban characteristics. Objective: To determine the prevalence of Paracoccidioides brasiliensis ifection in HIV positive individuals in the specialized service for HIV/aids in Campo Grande, MS. It was done the intradermal test gp43 glycoprotein in 90 HIV/aids patients living in the city of Campo Grande, MS, and followed in the HIV/aids clinic of the University Hospital. The patient was considered reactor if the resulting induration observed 48 hours after the application was ≥ 5mm. 74 patients showed no induration, 5 showed induration from 1 to 4mm in diameter, 7 patients with induration from 5 to 9mm, 3 patients with induration from 10 to 19mm and a patient with induration greater than 20mm. There were 11 patients with intradermal reaction to gp43, resulting in an overall prevalence of 12.2%. In patients with CD4> = 200 cells/mm3, the prevalence was 13%, and in patients with CD4 <200 cells/mm3 the prevalence was 9.9%. The sample studied, more than half (57.78%) had lived, or lived in rural areas. There were no statistically significant differences in socio-demographic variables and habits of life among reactor and non-reactor patients. This is the first study to evaluate the prevalence of infection in Paracoccidioides HIV/aids patients. The prevalence of infection with P. brasiliensis in patients HIV/aids in Campo Grande, MS, is estimated at 12.2%. The prevalence may be even greater considering that HIV/aids patients may not respond to the intradermal test which depends on the cellular immunity integrity for its positivity.