Doença cardiovascular em pacientes com espondiloartrite do ambulatório de reumatologia do hospital universitário da UFMS

Abstract

Introduction: Cardiovascular diseases are a major cause of morbidity and mortality today. Despite its wide distribution, it presents particularly prevalent in certain groups of individuals, particularly when exposed to a higher degree of inflammation, giving increased cardiovascular risk. Rheumatic diseases expose their holders to this increased cardiovascular risk condition; however only recently have been associated with spondyloarthritis. For being a classically autoimmune disease related to HLA histocompatibility system, spondyloarthritis may present phenotypic variations in different ethnic groups with possible diverse cardiovascular consequences. Objectives: To estimate the prevalence of cardiovascular disease (CVD) and cardiovascular risk profile by correlating the time of diagnosis and activity of spondyloarthritis in rheumatology outpatients at the University Hospital of UFMS. Methods: 50 patients with spondyloarthritis (SpA) compared by cross-sectional study with a control group (CG). Excluded diabetics, indigenous and pregnant women. Both group had measurement of lipid profile and inflammatory markers, ECG, echocardiogram, carotid ultrasonography and were stratified by global cardiovascular risk. The spondyloarthritis patients had evaluated the activity and commitment of the disease (BASMI, BASDAI, BASFI and ASDAS). Results: Average age: 42.46 ± 1.23 years, SpA diagnostic time: 9.58 ± 1.20 years. There was no difference in cardiovascular risk stratification among the groups most at intermediate and high risk (SpA: 52% and CG: 62%, p = 0.258) .Prevalence CVD manifests was low (~ 2%), with no difference between groups, except for right bundle branch block (SpA: 14% and CG: 2%, p = 0.027). There was no statistical difference of subclinical CVD between the groups, but with averages of carotid intima-media thickness (SpA: 1.6 ± 0.04 and CG: 0.7 ± 0.00, p = 0.016) and microalbuminuria (SpA: 8 01 and GC 1.76 ± 3.87 ± 0.95, p = 0.042) higher in the group with SpA. There was no correlation between disease activity and inflammatory markers and cardiovascular disease, but with time diagnostic SpA and intima-media thickness of carotid artery (p = 0.039, r = 0.328) .Conclusions: The prevalence of CVD risk factors was similar between groups. The degree of subclinical atherosclerosis was higher in spondyloarthritis, related to the time of diagnosis and independent cardiovascular risk factors or degree of inflammation. Most of SpA patients are exposed to high cardiovascular risk.