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dc.creatorCarollo, Carlos Alexandre-
dc.creatorHellmann-Carollo, Aline Regina-
dc.creatorSiqueira, João Máximo de-
dc.creatorAlbuquerque, Sérgio-
dc.identifier.citationCAROLLO, Carlos Alexandre et al . ALKALOIDS AND A FLAVONOID FROM AERIAL PARTS (LEAVES AND TWIGS) OF DUGUETIA FURFURACEA - ANNONACEAE. J. Chil. Chem. Soc., Concepción , v. 51, n. 2, jun. 2006 . Disponible en <>. accedido en 14 feb. 2014.
dc.description.abstractABSTRACT - Duguetia furfuracea is a shrub of the Annonaceae family that occurs in several regions in Brazil. In the state of Mato Grosso do Sul this species often becomes an invading plant when the cerrado is turned into pastures. In the local folk medicine, its powdered seeds are mixed with water and used against pediculosis, and the infusion of twigs and leaves is used to treat rheumatism.. The present work led to the isolation and characterization from the aerial parts of the plant (leaves and twigs), of twelve isoquinoline alkaloids of aporphine oxoaporphine, bisbenzyltetrahydro-isoquinoline, benzyltetrahydro-isoquinoline and tetrahydroprotoberberine skeletons. In addition b-sytosterol and the flavonoid isorhamnethin were obtained. The activity of these different patterns of isoquinoline skeleton and the flavonoid was tested against Trypanosoma cruzi, and only aporphinoid skeleton with (R)-configuration, (-)-asimilobine, was really effective against trypomastigotes (strain Y), killing approximately 72% of the parasites at a maximal concentration of 128.0 mM (IC50 57.2 mM). The trypanocidal activity of the alkaloids and the flavonoid have been investigated.pt_BR
dc.publisherJournal of the Chilean Chemical Societypt_BR
dc.rightsAcesso Abertopt_BR
dc.subjectTrypanosoma Cruzipt_BR
dc.titleAlkaloids and a flavonoid from aerial parts (leaves and twigs) of Duguetia furfuracea - annonaceaept_BR
dc.typeArtigo de Periódicopt_BR
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