Atividade enzimática e susceptibilidade antifúngica de candida spp. isoladas de pacientes com candidemia em hospital universitário de Campo Grande-MS, 1998-2010

Abstract

While Candida enzymes production in oral and vaginal samples has been extensively studied, there have been very few investigations with blood samples and clinical aspects. The aim of this work to study the epidemiological and clinical aspects of candidemia in patients admritted to Government Hospital of Mato Grosso do Sul and investigate virulence factors in the etiologic agents. A total of 137 Candida , included 61 C. albicans, 45 C. parapsilosis, 19 C. tropicalis, 9 C. glabrata, 2 C. krusei and 1 C. guilhermondii were recovered from patients at University Hospital in Campo Grande, Mato Grosso do Sul, Brazil. There was significant difference in the expression levels of phospholipase among Candida albicans and non-C. albicans Candida isolates. Most patients were admitted to the Intensive Care Unit (62.0%). No significant correlation was observed between the enzymes activities studied and the patient's fatal outcome. No samples showed resistance in vitro against fluconazole, itraconazole and amphotericin B.