OBTENÇÃO E ESTUDO DE ESTABILIDADE DE XAROPES CONTENDO PIMOBENDANA PARA USO VETERINÁRIO

Abstract

In recent years, there has been a significant increase in the life expectancy of domestic animals, with cats and dogs living considerably longer than before. This increase in longevity has led to an increase in cases of age-related diseases, advances in veterinary medicine and improvements in pharmacological treatments. Cardiovascular diseases, especially congestive heart failure (CHF), represent a significant concern due to their often silent nature and difficulty in diagnosing early. Pimobendan is widely used in the treatment of CHF in dogs, due to its fewer adverse effects and improvement in the quality of life and survival of animals. At the same time, the Brazilian compounding market stands out in the personalized compounding of veterinary drugs, providing more appropriate treatments for different species and breeds of domestic animals. The objective of this research was to obtain liquid pharmaceutical instructions (syrups) for animal use containing pimobendan, evaluate their stability and perform the quantification of the drug in different pharmaceutical bases, in order to generate comparative and conclusive information on which syrup is the most suitable for the active ingredient. To obtain the oral liquid formulations containing pimobendan, quality control tests were performed, such as macroscopic analysis of color and odor, pH, density, specificity and content determination, in addition to microbiological testing. These syrup bases containing pimobendan were subjected to a stability study under controlled storage conditions for 60 days. Syrups containing pimobendan, in different liquid formulations, Pimo-S® and artificial syrup showed positive behavior in terms of physicochemical and microbiological analyzes for the investigated period of 60 days.