Avaliação de compósitos de poliuretana de mamona e vidros bioativos dopados com e sem prata, como material protético

Abstract

The development of new biomaterials is a multidisciplinary area and has mainly focused on improving the quality of life. The castor bean polymer is biocompatible and it has already been used as bone substitute. However, its composition can be improved by using reinforcing fillers such as bioactive glass, seeking a faster and better osteogenesis (bone formation). In this work, a comprehensive study of the castor bean polyurethane biocomposite (PU), and bioactive glass (BG) of composition 60% Si-36% CaO - 4% P2O2 (mol%) was performed. Both pure VB and VB doped with various concentrations of silver (VBAg) were used. The Sol-Gel method was applied to prepare the VB and VBAg particles. This study proved to be quite complex, since it firstly characterized the physicochemical properties of the bioactive glass, secondly the physical-chemical properties of its PU composites, and finally the biological properties of the composites in vivo and in femurs of rats in vitro using Simulated Body Fluid (SBF) in order to correlate the properties of the elements of the composite with its synergistic properties. The analyses were performed by Scanning Electron Microscopy (SEM), Differential Scanning Calorimetry (DSC), Thermogravimetric analysis (TGA), X-ray diffractometry (XRD) and Fourier transform infrared spectroscopy (FT-IR). The composites with VBAg had higher bioactivity in SBF, but the composites of VB showed better adhesion to the bone, osteoconductivity and speed of bone formation in vivo.