Efeito dos recursos eletrofísicos na cicatrização tecidual em modelos experimentais diabético e renal

Abstract

Diabetes is a condition that results in increased blood sugar levels. With insufficient or even absent production of insulin, the body ends up being subjected to hyperglycemia. Kidney disease in diabetes is characterized by decreased renal filtration rate and proteinuria. This impaired performance is directly associated with increased blood pressure as well as an increased risk for cardiovascular disease. These conditions are also complicating factors in wound healing, these patients are increasingly frequent in physiotherapeutic rehabilitation. In this sense, the objective of this study was to evaluate and describe the effect of electrophysical resources (laser therapy, ILIB and cryotherapy) on tissue healing in experimental diabetic and renal models in wound healing, as well as possible systemic changes The animals were randomized into four groups: G1- healthy control with untreated injury, G2 - healthy control with injury and treatment, G3 - disease control with untreated lesion and, G4 - disease with injury and treatment. Furthermore, the treated groups were divided into 3, according to the type of treatment. All animals were induced to neurotendinous injury and treated according to the therapeutic protocols. Healing and inflammation were analyzed by semiquantitative histopathological study. It was observed in sick animals, treated with cryotherapy and ILIB, reduction of inflammatory exudate, presence of fibroblasts and organization of collagen cells, when compared to the effects of LLLT. Moreover, there was a reduction in glycemic levels in the group treated with ILIB. Cryotherapy proved to be efficient, revealing a reduction in inflammatory exudate and organization of collagen fibers, in addition to the absence of signs of tissue necrosis, in the groups treated with and without the disease. ILIB therapy showed these findings and a significant reduction in glycemic levels in the group of sick animals. The application of LLLT in the groups did not present satisfactory results in relation to the control groups. This study in a model of associated diseases (diabetes and kidney disease) whose effects of electrophysical resources studied after neurotendinous injury, allows us to verify histopathological variables suggestive of patients with the same comorbidities.