Potencial terapêutico das células-tronco mesenquimais de gordura em lesão do tendão de Aquiles em coelhos

Abstract

The aim of this work vas to study the therpapeutic potential of mesenchymal stem cells (MSC) in the complete injury of the Achilles tendon in rabbits by histologic analysis. For both New Zealand rabbits were distributed among six groups (n=5). Statistical analysis was performed by Mann Whitney and Kruskal Wallis test (p> 0,005). Reducing inflammation between periods was observed in the rupture and rupture + MSC groups. As for the capillars, rupture group got smaller number than the other within 14 days. There was a higher number of arterioles in group rupture + suture than the other within 14 days. The structural disorganization was higher in the group of rupture compared to the other within 14 days. There was no diferrence between the periods of the rupture group with the highest value for the period of 14 days compared to 28 days, the same occurred in the rupture group + MSC. Based on these we can infer that the use of MSC in injury of the Achilles tendon of rabbits not sutured was similar to using the gold standard method, ie, suturing the tendon.