DINÂMICA DA PROTEÍNA C REATIVA E DA IMUNOGLOBULINA E TOTAL EM PACIENTES PORTADORES DE PÊNFIGO FOLIÁCEO ENDÊMICO

Abstract

INTRODUCTION: Endemic pemphigus foliaceus (EPF), autoimmune bullous disease that preserves mucous membranes, prevalent in the Midwest and Northern Brazil, is connected to an environmental factor that involves exposure to insect bites. Reactions to insect bites are related to responses through immunoglobulin E (IgE). In the acute phases of EPF, frequent and intense inflammatory responses occur, which can be expressed through several mediators, including C-reactive protein (CRP). OBJECTIVES: To verify the dynamics of total IgE and CRP in EPF. METHODS: A quantitative, retrospective, non-paired study with non-probabilistic sampling by trial, evaluating patient charts of the Hospital Adventista do Pênfigo, from July 2014 to August 2017, selecting 52 cases evaluated in four evolutionary moments containing the data of clinical scores , IgE, and CRP, comparing them with a demographic questionnaire and subjecting them to statistical analysis.RESULTS: 1 - There was significance in the Mann-Whitney test (p = 0.009) in the quantitative comparison of the clinical scores and the total IgE, at the first moment of the four evaluations. 2 - In the qualitative analysis between the clinical scores and the percentage of altered IgE results, there was significance by Fisher's exact test (p = 0.001). 3 - In the CRP results there was incongruence between the clinical scores and the laboratory data. 4 - Additionally, the CRP presented irregularity of the percentage data. CONCLUSIONS: This study opens up additional possibilities in the use of IgE dynamics in the clinical follow - up of EPF cases. Further, multicenter, prospective studies are needed to validate the potential of the use of IgE dosages, obtained serially, in the monitoring of disease severity and evolution. The serial dose of CRP in this study presented incongruent results with the clinical evolution. Additional studies are required to re-evaluate the use of this test in EPF.