Potencial Catalítico de Sais de Hidróxidos Lamelares de Cobre (II) e Nanopartículas de Cobre suportadas em vidro na Reação “Click” para Síntese de 1,2,3-Triazóis

Abstract

"Click chemistry" stands out for its potential in creating matrices and substances with useful properties, promoting efficient, versatile and selective syntheses, with simple reactions. An important example is the 1,3-dipolar cycloaddition between alkyne and organic azide, catalyzed by Cu(I) (CuAAC), which results in the formation of 1,4-disubstituted 1,2,3-triazole. The development of simple, efficient and easily accessible catalysts for these reactions is highly desirable. In this sense, this work uses and compares two types of copper-based catalysts. The application of layered copper (II) hydroxide salts and copper nanoparticles were studied for their catalytic potential in the "Click" reaction of 1,3-dipolar azide-alkyne cycloaddition, catalyzed by copper, to obtain a 1,2,3-triazole 1,4-disubstituted derivative, under mild reaction conditions and without solvent. The results of catalysis by copper(II) layered hydroxide salts were promising, presenting good yields and regioselectivity, in addition to indicating that the 1,3-dipolar azide-alkyne cycloaddition reaction can be catalyzed via Cu(II). On the other hand, Cu nanoparticles obtained less satisfactory results due to the longer reaction time and the formation of by-products. The comparative study of the catalysis between the two compounds revealed that the differences in the properties and characteristics of the catalysts were significant for the results obtained. Finally, it was concluded that the azide-alkyne cycloaddition reaction catalyzed by both catalysts is in accordance with the conditions proposed for a "Click" chemistry.