AVALIAÇÃO DO EFEITO DO ÓLEO DE GIRASSOL OZONIZADO NO PROCESSO DE REPARAÇÃO TECIDUAL EM LESÕES PROVOCADAS POR QUEIMADURAS EM RATOS

Abstract

This project evaluated the viability of ozonized oleic compounds in direct topical application as a proposal for the treatment of burn injuries, by comparing them with conventional therapeutic proposals. 36 Wistar rats (Rattus norvegicus) were randomly selected to make up 3 distinct groups of 12 individuals, in which 2 burn injuries of 1 cm in diameter were induced on the back of each one, where each rat received a pre-established therapeutic approach, thus group 1 (G1) or control received a dressing with primary coverage of 1% silver sulfadiazine, Group 2 (G2) or Ozone + received primary coverage with 1% silver sulfadiazine and local application of ozonized sunflower oil over the entire length of the wound, Group 3 - Ozone received a dressing with local application of ozonized oil over the entire length of the wound in order to cover it, all the procedures were repeated every 24 hours by the researchers. The animals in the study were euthanized on the 4th, 8th and 12th days and skin samples were taken from the lesion and part of the adjacent healthy tissue. During the macroscopic evaluation, it was observed that there was no significant variation between the animals evaluated in terms of the potential for retraction and wound closure. During the microscopic evaluation, greater vascular neoformation was observed in the groups treated with ozonated oil, and a greater deposition of collagen fibers was also observed in rats treated with this substance.