AVALIAÇÃO DA CAPACIDADE REDUTORA DA VITAMINA C EM FORMULAÇÕES CONTENDO PALMITATO DE ASCORBILA

Abstract

Vitamin C, or ascorbic acid, is a water-soluble substance that has gained significant recognition, particularly for its aesthetic benefits. With the understanding that it is effective in combating free radicals and essential for collagen production, the cosmetic industry has expanded its topical applications, incorporating it into various formulations available in the market. Considering this, the present project aimed to conduct a comparative analysis of three pharmaceutical facial serum formulations containing nanoencapsulated ascorbyl palmitate. This experimental laboratory study compared products from different brands and subjected them to a DPPH radical reduction test, aiming to assess and compare the efficacy of their reducing activity, as well as an active release test in water. The data obtained from the DPPH radical reduction test showed that formulation F1 demonstrated a gradual decrease in IC50, similar to the quercetin standard. F2 initially showed a reduction but later increased again. In contrast, F3 did not exhibit the same reduction behavior, suggesting a pro-oxidant effect. In the release test, sequential release was observed in all samples, but F1 stood out with a release percentage of 62.67%, while the others did not exceed 5%. It was concluded that the concentrations of compounds, ingredient compatibility, and the material of the nanoparticles may influence the reducing capacity and release of this vitamin C derivative in the tested formulations.