AVALIAÇÃO DAS ATIVIDADES ANTI-INFLAMATÓRIA E ANALGÉSICA DO EXTRATO AQUOSO OBTIDO DO CAULE DE Serjania marginata EM CAMUNDONGOS

Abstract

Anti-inflammatories are drugs with broad therapeutic action, used to treat symptoms such as fever, pain and inflammation. Excessive use of these drugs can cause known adverse effects, such as: gastrointestinal, renal, cardiovascular problems and bronchospasms. In view of this, the search for new alternatives for the treatment of inflammatory diseases and a lower incidence of adverse reactions becomes relevant. The use of medicinal plants as a form of treatment of illnesses has been around for a long time, with several reports of ancient civilizations and indigenous tribes using medicinal plants to treat illnesses. Thus, over time, a huge experimental portfolio on their benefits has been carried by man. Serjania marginata Casar, native to Mato Grosso do Sul, has already been described in the literature as having anti-inflammatory activity, involving an extract obtained from the leaves of this plant. However, studies evaluating the anti-inflammatory and analgesic potential of the stem of this plant are still lacking. Therefore, this study aimed to evaluate the anti-inflammatory and analgesic potential of the aqueous extract of the stem of S. marginata (SM-LG). For this purpose, we evaluated the effect of the extract on the acute inflammatory response and on nociception in Swiss mice. Our results demonstrated that treatment with SM-LG reduced leukocyte recruitment in a model of peritonitis induced by zymosan in Swiss mice, in addition to reducing the formation of edema and mechanical hyperalgesia induced by carrageenan. Additionally, treatment with SM-LG also reduced nociception induced by formalin and acetic acid in mice. In conclusion, treatment with SM-LG showed anti-inflammatory and antinociceptive activity during the experimental acute inflammatory response.