DSpace Coleção:https://repositorio.ufms.br/handle/123456789/91142026-04-09T23:28:16Z2026-04-09T23:28:16ZPontos quânticos de carbono funcionalizados com curcumina: eficácia fotodinâmica em larvas de Aedes aegyptihttps://repositorio.ufms.br/handle/123456789/141682025-12-18T21:47:15Z2025-01-01T00:00:00ZTítulo: Pontos quânticos de carbono funcionalizados com curcumina: eficácia fotodinâmica em larvas de Aedes aegypti
Abstract: Arboviruses transmitted by Aedes aegypti remain a major public health challenge,
and vector control based on chemical insecticides faces limitations related to efficacy,
resistance, and environmental impact. In this context, it is relevant to develop aqueous
photosensitizers selective for the larval stage of the vector. This work aimed to synthesize,
characterize, and compare pristine carbon quantum dots (CQ-Dots) and curcumin-loaded
carbon quantum dots (CQD-Cur) regarding their potential for photodynamic control of
3rd-instar A. aegypti larvae. CQ-Dots were obtained via a microwave-assisted bottom-up
route using dextrose as a carbon precursor and subsequently functionalized with curcumin
to yield CQD-Cur. The samples were characterized by UV-Vis absorption, fluorescence
spectroscopy, FTIR, dynamic light scattering, zeta potential, and atomic force
microscopy; confocal microscopy in Artemia sp. and A. aegypti larvae was used to assess
internalization. Ecotoxicity assays in Artemia sp. and photodynamic tests under RGB
LED and sunlight irradiation allowed correlation of physicochemical properties, reactive
oxygen species generation (ROS), and larval mortality. Results indicate that both systems
generate ROS and accumulate in the digestive tract, but only CQD-Cur promotes
significant photoinactivation of the larvae, without a marked increase in dark toxicity.
These findings suggest that curcumin-functionalized carbon quantum dots constitute a
promising and potentially more sustainable approach to complement the integrated
management of A. aegypti populations.
Tipo: Trabalho de Conclusão de Curso2025-01-01T00:00:00ZGeração e Controle de Pulsos de Radiofrequência para um Protótipo de Imagem por Ressonância Magnéticahttps://repositorio.ufms.br/handle/123456789/138482025-12-05T16:47:39Z2025-01-01T00:00:00ZTítulo: Geração e Controle de Pulsos de Radiofrequência para um Protótipo de Imagem por Ressonância Magnética
Abstract: Magnetic Resonance Imaging is a non-invasive, high-resolution imaging technique widely used in medicine for its ability to differentiate soft tissues without the use of ionizing radiation. However, there is a significant inequality in access to such equipment across Brazil, with large regions showing limited or no availability of MRI exams. The development of national MRI equipment represents an alternative to reduce costs and expand access, promoting technological autonomy. In this context, the CNPEM has been developing expertise in this field and currently has a 0.4 T MRI prototype partially developed at the center, except for the gradient amplifiers, power amplifiers, and console.
This work marks the beginning of the console development, focusing on the RF transmission system. The objective was to design and validate a digital RF pulse generator implemented on a Field-Programmable Gate Array (FPGA), using the Red Pitaya development board and the VHSIC Hardware Description Language (VHDL). The methodology employed the Direct Digital Synthesis (DDS) technique for generating sine and cosine carriers through a Numerically Controlled Oscillator (NCO), combined with quadrature (IQ) modulation. The digital design was developed in VHDL and validated through testbenches in a simulation environment using Vivado software. Simulation results demonstrated the correct integration of the modules and the generation of the pulse with frequency matching the control parameter. This behavior validated the frequency-controlled signal generation using the DDS technique and pulse modulation. Bench tests showed a modulated pulse on the oscilloscope consistent with the simulations, confirming the correct FPGA implementation for RF pulse generation, with experimental values close to those obtained in simulation. This work contributed to the team’s technical training and served as an initial step in the development of the conceptual console. The results obtained in this process can be further optimized and improved to support CNPEM’s goal of developing a fully national MRI system in the future.
Tipo: Trabalho de Conclusão de Curso2025-01-01T00:00:00ZFotodiagnóstico de Tuberculose Bovina por Espectroscopia no Infravermelhohttps://repositorio.ufms.br/handle/123456789/137792025-12-04T19:40:17Z2025-01-01T00:00:00ZTítulo: Fotodiagnóstico de Tuberculose Bovina por Espectroscopia no Infravermelho
Abstract: A tuberculose bovina é uma zoonose de grande impacto causada por Mycobacterium bovis, que traz prejuízos econômicos e riscos à saúde pública, agravados pelas limitações dos métodos diagnósticos tradicionais, frequentemente invasivos e de baixa acessibilidade. Este estudo avaliou o potencial da espectroscopia no infravermelho por transformada de Fourier (FTIR) aliada ao pré-processamento SNV e, em seguidas, submetidos à redução de dimensionalidade por PCA e à classificação por SVM para distinguir entre soros bovinos infectados e controles. As 80 amostras foram analisadas, e a abordagem revelou assinaturas espectrais capazes de discriminar os grupos. O modelo SVM linear apresentou validação cruzada (LOOCV) com acurácia de 70%, sensibilidade de 80% para os infectados e especificidade de 60% para os controles, destacando a viabilidade da técnica em contextos com infraestrutura limitada. Conclui-se que a integração entre FTIR e aprendizado de máquina permite diagnósticos mais eficientes e acessíveis, auxiliando o controle da tuberculose bovina.
Tipo: Trabalho de Conclusão de Curso2025-01-01T00:00:00ZEfeitos da incorporação de pontos de carbono sobre a matriz de óxido de grafeno reduzido no armazenamento de energia.https://repositorio.ufms.br/handle/123456789/137242025-12-03T23:36:50Z2025-01-01T00:00:00ZTítulo: Efeitos da incorporação de pontos de carbono sobre a matriz de óxido de grafeno reduzido no armazenamento de energia.
Abstract: The transition to renewable energy sources increases the demand for efficient energy storage systems. Supercapacitors stand out in this scenario due to their high power density and long cycle life; however, their low energy density motivates the search for new electrode materials. This work investigated the potential of aerographene (ArGO) and carbon dots (CDs) composites to overcome this limitation. Pure aerographene and composites with three different CDs mass ratios (1%, 5%, and 10%) were synthesized, subjected to thermal treatment, and morphologically characterized by scanning electron microscopy (SEM). The electrochemical performance was evaluated by cyclic voltammetry and galvanostatic charge/discharge tests in a 1M H₂SO₄ electrolyte. The results demonstrate that thermal treatment and the incorporation of CDs significantly optimize performance. Specifically, the composite with 10% CDs submitted to thermal treatment achieved a specific capacitance of 625.13 F·g⁻¹ while maintaining electrochemical stability. The Ragone plot analysis confirmed typical supercapacitor behavior, positioning the developed materials as promising candidates for application in high-performance energy storage devices.
Tipo: Trabalho de Conclusão de Curso2025-01-01T00:00:00Z